New sequencing technology helps solve some mysteries of E. coli outbreak

bacteriaby adonofrio

Pacific Biosciences DNA sequencing technology yields new insights into German E. coli pathogen
[Via Eureka! Science News – Popular science news]

An international team of scientists has successfully employed single molecule, real-time (SMRT™) DNA sequencing technology from Pacific Biosciences of California, Inc. (NASDAQ: PACB) to provide valuable insights into the pathogenicity and evolutionary origins of the highly virulent bacterium responsible for the German E. coli outbreak. Published online today in the New England Journal of Medicine, the results provide the most detailed genetic profile to date of the outbreak strain, including medically relevant information.

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The ability of next generation DNA sequencing techniques to rapidly look at a lot of different genomes almost simultaneously opens the door to rapidly understand why a disease outbreak occurs – such as what virulence factors are present and where they might have come from.

We will be generating huge databases of these organisms of disease in the coming years.