by tanakawho
Malaria-transmitting mosquito evolving, NIH grantees find
[Via EurekAlert! - Infectious and Emerging Diseases]
(NIH/National Institute of Allergy and Infectious Diseases) Researchers funded by NIH have found that the major malaria-transmitting mosquito species, Anopheles gambiae, is evolving into two separate species with different traits, a development that could both complicate malaria control efforts and potentially require new disease prevention methods. Their findings were published in back-to-back articles in the Oct. 22 issue of the journal Science.
A. gambiae is the most common vector of human malaria in sub-Saharan Africa, where rates of the disease are highest. The researchers compared the genomes of two emerging species, dubbed M and S. Given that M and S appear to be physically indistinguishable and interbreed often, they were unexpectedly different at the DNA level. They also were found to behave differently and thrive in different habitats. For example, in the absence of predators, S mosquitoes outcompeted M mosquitoes, but the outcome was reversed when predators were present.
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I wrote earlier about recent work on the evolution of the Cane Toad. Creationists postulate a model which does not require firmly understanding the process of evolution in any detail. Gaining greater understanding of what is happening is not much of a goal for them.
This story demonstrates why having a good scientific model for understanding a process in the natural world can have real ramifications on human health. First off, an understanding of evolution underpins the research tools they use, such as the DNA sequence data they generated. we really only discovered the changes that are happening because of the tools of molecular biology.
While there appears to still be a lot of interbreeding between the two, the DNA suggests that not many genes flow between the two forms. Mating does not yet result in infertile hybrids. But if they are mating a lot, there should be lots of gene flow. What is going on? How can they be in the process of speciation?
It turns out that the different forms are being selected at the larval stage. The S-form is found in natural, ephemeral and predator-free pools of water. The M-form is found in water pools created by man and that often have predators. This is where the selection is taking place to create two species.
And this is what is happening throughout the genome, suggesting that speciation is actually fairly well advanced.. One region is know to be important for resistance to insecticides. The two forms carry two different mutations in this region, each of which confers resistance.
So, these two forms have not advanced far enough to the pint where they can no longer interbreed. And they can still produce offspring. But the specific form is selected at the larval stage, negating any interbreeding going on and restricting gene flow.
Now, for them to continue separating, they need to stop wasting their time interbreeding since it wastes their genes – the hybrid offspring get driven towards one form of the other. Well, it turns out that another area where there are genomic changed encompass odorant receptors – used to smell – that are involved in female sexual receptivity. They are starting to distinguish the right mate by smell.
These two types of mosquitoes are being selected via two different environments. Targeting human created pools of water would only affect one form. Since one likes human-created pools, this very speciation event may be driven by humans.The same might be seen with insecticide resistance.
Because we have the tools for understanding it and the scientific model to explain it, the importance of evolution for helping us work towards control of a disease carrying pest is pretty easy to see. Creationism provides no valid scientific model and would not provide us with any understanding of what was happening with these mosquitoes.

