Listenin’ and thinkin’ ’bout Fosse

201001211728.jpg by Clifford Michael

I was going to write something but this happened.

[Listening to: Maybe This Time (Glee Cast Version) [feat. Kristin Chenoweth] from the album Glee – The Music, Vol. 1 by Glee Cast]

I just LOVE this version. I want to see Glee just do an entire show based on musical numbers connected to Bob Fosse. We could use the films Cabaret (Money would be nice, as would Cabaret) and All that Jazz (Everything Old Is New Again), along with ones such as Kiss Me Kate (Brush Up Your Shakespeare or Too Darn Hot), The Pajama Game (Hey, There as a self-duet would be neat) and Damn Yankees (Whatever Lola Wants is obvious for Sue but I think Those Were the Good Old Days would better since a great voice is not required and it really fits her as ‘pure evil.’) And those stage musicals, such as Chicago (Just about anything but I think Roxie, Mister Cellophane, Razzle Dazzle or When You’re Good To Momma would be a good fit.), Sweet Charity (Big Spender or If My Friends Could See Me Now), How to Succeed in Business Without Really Trying (I Believe in You), and Pippin (Magic to Do would seem to be a great fit).

Now I have to go watch All That Jazz as it is one of my favorite movies about making movies. Then maybe the film version of Kiss Me Kate so I can watch him dance. Of course, thanks to Youtube, I can watch Fosse dance with George Burns or from the Affairs of Dobie Gillis. Evenewhen he is doing ‘standard’ routines for the time, he pulls you in to watch him. I think it is those high water pants with white socks, and hand movements.

Which, of course was extended by Michael Jackson, as can be seen in this nice mashup of the two.

I wrote about it

nalgene bottle by celebdu

Boston Globe, Times, others: How much did FDA shift on BPA?
[Via Knight Science Journalism Tracker]

Over the weekend, the government announced that it would launch a $30 million study of the chemical bisphenol A, or BPA, to determine whether it’s safe in food and beverage containers, including baby bottles.

The FDA has also changed its position on BPA–but what exactly has it done? The coverage offers multiple interpretations.

Beth Daley of The Boston Globe paints a relatively soft portrait of the FDA’s action, although she does get baby bottles in the lede:

Acknowledging there is “some concern’’ that a chemical found in baby bottles and infant sipping cups could cause adverse heath effects in children, Food and Drug Administration officials pledged yesterday to study the chemical far more closely but said there was not enough evidence to further regulate it.

Lyndsey Layton of The Washington Post wrote a lede with considerably more oomph, saying the FDA”reversed” itself:

The Food and Drug Administration has reversed its position on the safety of Bisphenol A, a chemical found in plastic bottles, soda cans, food containers and thousands of consumer goods, saying it now has concerns about health risks.

Andrew Zajac in The Los Angeles Times wrote that FDA said the chemical “merited further study” but “no immediate restrictions on its use.” And Denise Grady at The New York Times wrote that the FDA “in a shift of position” was “expressing concerns” about bisphenol A, which it had “declared safe in 2008.”

The varying interpretations turn, I suppose, on whether “some concern” should be read as SOME concern, or some CONCERN. In the past, the FDA expressed little or no concern, so you might argue that any expression of concern was a big shift, or even a reversal. The other interpretation would be that the FDA had expressed some concern, but no particular alarm.

I’ll go out on a bit of a limb here, as someone who has written about the possible dangers of BPA in the past, and argue that this is a bit of an under-covered story. Environmental groups have expressed great alarm, and industry groups have tracked them very closely with press releases rebutting every argument. I’m making this claim without looking back over years of coverage; it’s just a feeling I have from being involved in the coverage. It was a little too easy to get a scoop on a new development, which leads me to think that not enough people were competing to cover this.

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I was amazed also. Lots of talk about what the FDA news meant, lots of opinions, when the facts were right there from a story that came out 2 days earlier. I wrote about it on my other blog, Path to Sustainable, but that blog is not has highly traveled as this one is.

As I mentioned ther, I have written about Bisphenol A (BPA) a lot. In fact, I thought that the results of this study, where BPA caused sexual problems in men, would have been enough to change the FDA’s views. Unfortunately, BPA can not be regulated at all by the FDA because it was put in the generally considered safe category 40 years ago. Chemicals in this group are completely outside the regulatory grasp of the FDA. AIn’t that great?

I am on the board of a non=profit now called the Sustainable Path Foundation. Back in 2004, we instituted the inaugural series of seminars that we continue to this day. The first speaker was Pete Myers, now head of Environmental Health Sciences. A major part of his discussion was on the current state of research on chemicals such as Bisphenol A. His seminar was a real eye-opener to y as a scientist.

That is because BPA was originally developed as an estrogen mimic but was not the best one so it was put on the shelf. Then someone, who was only interested in tis ability to make plastics, not its biological activity, picked it to use in polycarbonate bottle. Since it was in an inert plastic, there should be no effects.

But in the late 90s, it was found that BPA leached out of these bottle. And it had direct biological effects that could be seen in rodents. In fact, and this was the mouth -dropping thing for a scientist, was that it could be found in the water given to rats, if polycarbonate bottle were used instead of glass. So, any animal could be exposed to BPA, without any real knowledge of the researcher.

This was demonstrated when labs tried to replicate the initial research showing an effect of BPA. These labs saw little effect of BPA, not because BPA had no effect but because the control mice, which supposedly got no BPA, were, in fact, getting BPA from the water.

This actually would have ramifications across many mouse studies, because the control mice would often also be getting an estrogen disruptor. In essence, they were not really control mice at all.

Of course, the real concern for most of the scientists in the audience was that we had been using Nalgene plastic bottles since before the 70s. Using them as water bottles to drink out of!! Supposedly made out of nice, inert plastic, they were readily available and just the right size. In fact, Nalgene saw this and created the Nalgene bottle used for such a long time by hikers. But we all DRANK out of these bottle, just like the lab mice did.

Nalgene is transitioning away from these BPA-containing polycarbonate bottles (good for them) because I would not have drank another mouthful of water from a polycarbonate bottle.

The other thing that Myers showed was that exposure to estrogen disrupting chemicals during only a very short period of fetal development, had lifelong consequences on gene expression. Thus, two identical mice, only one exposed before birth, had very different expression pattern for a set of proteins. And the difference continued through out their lifespan.

Simply removing future exposure may not have any effect. The damage is already done.

The effects seen in mice from exposure to BPA –increased weight, diabetes – are also things seen in the last 40 years in humans. So we have a chemical that, if present at the right time during development, completely changes lifetime gene expression patterns, resulting in overweight, diabetic animals.

Yet, the FDA is completely unable to regulate it. And, guess what, the relevant companies are doing the tobacco company scam to keep it that way.

How come little of this context ever appears in the mainstream media? BPA is a scary compound and its makers are using tactics that are associated with known dissemblers like tobacco companies.

Why not remember this, including the companies in this list, and wonder why more reporters do not connect the dots:

Government is funny; there is a Democratic version of the facts, and a Republican version of the facts. And a Limbaugh version, and a Howard Dean version. And so on. Science writers are in possession of what I guess I now have to call actual facts, or real facts. Let’s not let the mouthpieces control the “facts,” when we know better.

[Listening to: Abaddon's Bolero from the album "Trilogy" by Emerson, Lake & Palmer]

My hope – The West Wing

I wrote about this last fall, how the West Wing began with the first term of a Democratic President, whose only first year plus was a new Supreme Court justice. Sound familiar.

The came the episode, Let Bartlet Be Bartlet. It changed everything. Because Bartlet decided doing the right thing was more important than doing the safe thing. That is leadership.

I really wish something like this was going on in the White House but I know that in reality, little will change.

Perhaps if Obama, and the rest of the Democratic leadership, knew that doing the right thing is more important than doing the safe thing, they would actually get things done. They would sure be more constructive than they have been. In one short year, they have demoralized their own base, alienated large amounts of independents and energized the opposition. That is leadership you can get behind. As long as you are a Republican.

Giving up on single payer, public options and progressive taxation while throwing pro-choice issues under the bus, may not accomplish much of anything. Perhaps actually standing firm on some basic issues would have been better.

First Draft has a nice parable about two men traveling on a road to an important destination. A wall blocks their path. The first guy says, “Well. we tried. Lets go home.” The second begins trying to figure out a way around, over or through the wall. “Because it’s more important that we get where we’re going than that we have a really good reason for going home. “

Will Obama, Reid, Pelosi and any other leaders be the first person or the second? I’m not very certain which they will be and that indicates a terrible lack of real leadership.

Doing the safe thing has not been successful. Perhaps doing the right one will at least allow them to look at themselves in the mirror.

As for me, I’m rewatching the West Wing episode and hoping that in some way reality is some small shadow of this TV show. Because we have too many really big problems that have to be solved if the US is to maintain any leadership in economical, political, scientific or human rights areas.

We should not have gotten into the situation where the only hope is a Hail Mary pass but that is all we seem to have left.

[UPDATE] Looks like Krugman just about figures that Obama is the first person.

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Actually kind of a fun paper to read

cheerleader by Wigstruck

NCBI ROFL: I wonder if this paper was cheer-reviewed.
[Via Discoblog]

The potential for brain injury on selected surfaces used by cheerleaders.

“CONTEXT: Although playground surfaces have been investigated for fall impact attenuation, the surfaces that cheerleaders use have received little attention. OBJECTIVE: To determine (1) the critical height for selected surfaces used by cheerleaders at or below which a serious head impact injury from a fall is unlikely to occur, (2) the critical heights for non-impact-absorbing surfaces for comparison purposes, and (3) the effect of soil moisture and grass height on g(max) (which is defined as the multiple of g [acceleration due to gravity at the earth's surface at sea level: ie, 32.2 feet x s(-1) x s(-1)] that represents the maximum deceleration experienced during an impact) and the Head Injury Criterion (HIC) at the critical height for a dry grass surface. DESIGN: Observational study. SETTINGS: A local cheerleading gym, indoor locations within the authors’ institution, and various outdoor locations… …RESULTS: Critical heights for the surfaces tested ranged from 0.5 ft (0.15 m) for concrete and vinyl tile installed over concrete to more than 11 ft (3.35 m) for a spring floor… …CONCLUSIONS: The potential for serious head impact injuries can be minimized by increasing the shock-absorbing capacity of the surface, decreasing the height from which the person falls, or both.”

cheer_fall

Thanks to Vanessa for today’s ROFL!

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The actual paper is wonderfully open access so any of us can rad it without having to pay an arm and a leg. It is easy to make fun of cheerleaders but these are often a group of teenaged students who put their physical wellbeing in potential danger. We know different surfaces would have an impact on head trauma but not how much nor how current guidelines actually protect the students.

So, while it is a fun article, there are some important questions to be answered.

They measured the deceleration of a headform on various surfaces and then used the same Head Injury Criterion used by crash test dummies. People had done this with football players, especially with concussions but no one had looked at these factors for cheerleaders. 54% of catastrophic fall-related injuries for cheerleaders were head-related.

With all the concern now about head injuries in football, mainly because we are getting real data now rather than conjecture, these authors looked at cheerleaders. SInce some of their stunts put the person’s head at heights over 15 feet above the ground, having some firm numbers would be useful.

So, actually having some directly relate numbers would be useful for guiding the squads on where to workout would be helpful. Where this get fun is descriptions such as this:

Carpet and the vinyl tile floor were tested in the authors’ office building.

I have the vision of them dropping a headform in the lobby while people stroll by. They used the Triax 2000 Portable Surface Impact Tester.


201001210929.jpg

This looks like it would be a lot of fun to set up and use on all sorts of things. One thing they failed to measure is the HIC if the headform landed on someone. This is usually what happens in real cheerleading. I’d love to think of a grad student laying down underneath the tripod waiting for the headform to be dropped from different heights.

And in order to be completely thorough they measured the ambient temperature, humidity and soil moisture. Pretty rigorous.

One thing they found was that wet, moist grass/soil reduced the deceleration pretty substantially – almost in half. But, according to their data, the critical height on dry grass is almost the same as on a hardwood floor – about 4.5 feet.

In fact, their data indicate that the guidelines used for cheerleader safety may not be effective. The American Association of Cheerleading Coaches and Administrators created these for safety reasons but these do not seem to be based on the sort of data this paper developed.

So all those cheerleading competitions on ESPN may have to be changed.

Simple scan spots stress disorder

brain surgery by brain_blogger

Simple scan spots stress disorder
[Via BBC News | Science/Nature | World Edition]

A one-minute test appears to diagnose post-traumatic stress disorder with an accuracy of 90%.

The test measures the tiny magnetic fluctuations that occur as groups of neurons fire in synchrony, even when subjects are not thinking of anything.

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A simple brain scan could do a lot to help. We would still need to get people to come forward to get scanned. This hesitancy to be examined is a big hurdle.

But our continuing ability to find structural problems in the brain using these technologies holds out hope. PTSD is not just made up or in someone’s head. It produces real changes in the brain.

[Listening to: Trilogy from the album "Trilogy" by Emerson, Lake & Palmer]
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